How to inject NUCALA at home

Find the information you need to inject with confidence

Your healthcare provider will give you information you need to inject properly and about monitoring for any allergic reactions. Sometimes, serious allergic reactions, including anaphylaxis, can occur hours or days later. Here you can find videos, instructions, and other useful information on how to use the NUCALA Autoinjector or prefilled syringe for patients aged 12+.

Are you a caregiver to a patient aged 6-11?

Autoinjector

Prefilled syringe

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ONSCREEN TEXT:

[NUCALA logo: NUCALA (mepolizumab) Injection 100 mg/mL]
How to Use Your Prefilled Autoinjector

Please see the full Instructions for Use at NUCALA.com

WOMAN:
Hi. Today I’m going to help show you how to prepare for and take your NUCALA injection. First, your doctor should teach you how to use the Autoinjector. You should also read the full Instructions for Use in your NUCALA carton or at NUCALA.com.

I’ll walk you through the injection like your doctor may have. If you have questions or concerns, you can always talk to your doctor about NUCALA. And remember: You got this. It shouldn’t take long for you to get more comfortable with injecting medicine yourself. Let’s get started.

First, take the carton out of the refrigerator. Check to make sure the security seals aren’t broken. If a seal is broken, don’t use the Autoinjector and safely throw the carton away.

Now, take the tray out of the carton. Peel off the clear plastic cover, and, while holding the middle of the Autoinjector, carefully take it out. Before we begin, let’s look at the components of the Autoinjector.

ONSCREEN TEXT:
Do not remove the clear needle cap at this step.
[labels naming components of the Autoinjector]
Clear needle cap
Yellow needle guard (needle inside)
Stopper
Label
Inspection window (medicine inside)

WOMAN:
Don’t remove the clear needle cap at this step.

Check the expiration date on the label of your Autoinjector and make sure it hasn’t passed.

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Look at the medicine in the inspection window. It should be clear to pale yellow to pale brown in color and without cloudiness or particles.

WOMAN:
Look at the medicine in the inspection window. It’s normal to see one or more air bubbles. It should be clear to pale yellow to pale brown in color. If it’s cloudy, discolored, or has particles floating in it, don’t use it.

Now put the Autoinjector down on a clean, flat surface at room temperature, away from direct sunlight and out of the reach of children. Don’t try to warm it up any other way.

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Wait 30 minutes.

WOMAN:
You’ll need to wait 30 minutes before use.

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Do not use if left out more than 8 hours.

WOMAN:
Don’t use it if it’s left out of the carton more than 8 hours.

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Supplies you need
 

  • Alcohol swab

  • Cotton ball or gauze

  • Adhesive bandage

  • Sharps disposal container

WOMAN:
You can take this time to gather the supplies you need: an alcohol swab; a cotton ball or gauze; an adhesive bandage; and a sharps disposal container.

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The Autoinjector is only for use under the skin (subcutaneous).

WOMAN:
The Autoinjector is only for use under the skin.

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You can inject in your thigh or abdomen.
 

  • Do not inject where your skin is bruised, tender, red, or hard.

  • Do not inject within 2 inches of your belly button.

WOMAN:
Now you can choose your injection site. You can inject yourself in your thigh or abdomen.

ONSCREEN TEXT:
Your caregiver or healthcare provider can also inject in the upper arm.

WOMAN:
Or if you’re a caregiver or healthcare provider giving the injection to someone else, you can also choose to inject in the upper arm.

WOMAN and ONSCREEN TEXT:
If you need more than one injection to complete your dose, leave at least two inches between each injection site.

WOMAN:
Now, wash your hands well with soap and water.

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After cleaning the injection site, don’t touch the area again until after the injection.

WOMAN:
Clean the area you want to inject by wiping your skin with an alcohol swab and allowing it to air-dry.

Now remove the clear needle cap from the Autoinjector by pulling it straight off. This could take a little force. You may see a drop of medicine at the end of the needle, and that’s normal.

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Inject within 5 minutes after you remove the clear needle cap.

WOMAN:
Always inject within 5 minutes after you remove the clear needle cap. Do not touch the yellow needle guard with your fingers, and don’t put the needle cap back onto the Autoinjector, because that could accidentally start the injection.

Touching the yellow needle guard may also cause a needle injury.

Hold the Autoinjector so you can see its inspection window. Place the Autoinjector straight onto your injection site with the yellow needle guard flat on the surface of your skin.

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  • Push & Hold

  • 1st Click

  • 2nd Click

  • Count to 5

  • Lift

WOMAN:
To start your injection, push the whole Autoinjector all the way down and keep it held down against your skin. This will make the yellow needle guard slide up into the Autoinjector. If the yellow needle guard does not slide up, don’t use the Autoinjector; throw it away in a sharps disposal container.

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  • Push & Hold

  • 1st Click

  • 2nd Click

  • Count to 5

  • Lift

[graphic] 1st “Click”

WOMAN:
You should hear a click to let you know your injection has started. The yellow indicator will move down through the inspection window as you receive your dose. Don’t change the position of the Autoinjector, and hold it in place. Your injection may take up to 15 seconds to complete.

ONSCREEN TEXT:
 

  • Push & Hold

  • 1st Click

  • 2nd Click

  • Count to 5

  • Lift

[graphic] 2nd “Click”

WOMAN:
Continue to hold until you hear the second click, the stopper has stopped moving, and the inspection window is filled with the yellow indicator. If you don’t hear the second click, check that the inspection window is filled with the yellow indicator, or hold the Autoinjector down for 15 seconds to make sure the injection is complete.

After you hear the second click, continue to hold, and count to 5.

ONSCREEN TEXT:
 

  • Push & Hold

  • 1st Click

  • 2nd Click

  • Count to 5

  • Lift

[arrow graphic] Lift

WOMAN:
Then gently lift the Autoinjector away from your skin.

ONSCREEN TEXT:
Do not put the needle cap back on.
Do not rub your injection site.

WOMAN:
Do not put the needle cap back on. Don’t rub your injection site. You may see a small drop of blood, which is normal. Just press a cotton ball or gauze on the area and apply an adhesive bandage if you need it.

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[icon] Dispose of the used Autoinjector and needle cap in an FDA-cleared sharps disposal container right away.
[icon] Do not throw away your used sharps disposal container in your household trash unless your community guidelines permit this.
[icon] For more information about safe sharps disposal, visit www.fda.gov/safesharpsdisposal

WOMAN:
To clean up, put your used Autoinjector in a sharps disposal container right away, and keep the container out of the reach of children.

That’s it for the injection! Once you do a few of these, it should become just another part of your treatment routine.

ONSCREEN TEXT:
844-4-NUCALA
Monday – Friday, 8 AM – 8 PM ET

Nurses from MyNUCALA.com don’t give medical advice. Talk to your healthcare provider about any disease-, treatment-, or referral-related questions.

WOMAN:
If you have any questions or need more information, talk to your doctor. You can also call the Nurse Support Line at 844-4-NUCALA to get help with your injections or any general questions you have about NUCALA. For additional resources and support, you can turn to MyNUCALA. Look for it on NUCALA.com.

ONSCREEN TEXT:
Trademarks are owned by or licensed to the GSK group of companies.
©2019 GSK or licensor.
MPLVID220026 November 2022
Produced in USA.

Close
 

Instructions for injecting

Complete Instructions for Use Quick reference guide

Storage information

  • Store in the refrigerator between 36°F and 46°F (2°C and 8°C).
  • Keep in the original carton until time of use to protect from light.
  • Do not freeze. Do not shake. Keep away from heat.
  • If necessary, an unopened carton can be stored outside the refrigerator at up to 86°F (30°C) for up to 7 days.
  • Safely throw away the Autoinjector if it is left out of the refrigerator in the unopened carton for more than 7 days.
  • The Autoinjector must be used within 8 hours after you take it out of the carton. Safely throw it away if is not used within 8 hours.
  • Safely throw away medicine that is out of date or no longer needed.

Keep NUCALA and all medicines out of the reach of children.

Warning

Warnings

Do not use the Autoinjector more than 1 time. Throw away the Autoinjector in an FDA-cleared sharps disposal container after your injection.

Do not share the Autoinjector with other people. You may give other people a serious infection, or you may get a serious infection from them.

Do not use the Autoinjector if it was dropped or looks damaged.

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Autoinjector FAQs

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We’re here for you on your treatment journey

Whether you’re still thinking about starting NUCALA or have moved forward with NUCALA as a treatment option, MyNUCALA can support you along the way. MyNUCALA offers ways to help you track your progress, stay on your treatment plan, guide conversations with your doctor, and more.

Enroll today

The MyNUCALA Support Line is here to help answer questions about the self-injection process.

Call 1-844-4-NUCALA (844-468-2252), Monday – Friday, 8 AM – 8 PM ET.

If you have questions, contact your doctor or a healthcare provider to see if adding NUCALA for your severe asthma is right for you.

We have nurses* available to talk to you about NUCALA

844-4-NUCALA (844-468-2252)

*MyNUCALA nurses do not give medical advice, and will direct you to your doctor for any disease-, treatment-, or referral-related questions.

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