What is NUCALA?

NUCALA is a different kind of treatment for your severe asthma. It's an injection you get in your doctor's office once every 4 weeks. When added to your current asthma medications, NUCALA may decrease airway inflammation that may trigger severe asthma attacks.

How is NUCALA different?

  • It's not a steroid or an inhaler.
  • It targets eosinophils, one source of inflammation, so it treats more than just your symptoms of severe asthma.

What are the benefits of NUCALA?

Add NUCALA to your asthma medications to:

Prevent severe asthma attacks
Studies have proven that NUCALA significantly reduced the occurrence of severe asthma attacks by more than half, even those that led to ER visits or hospitalizations. Your results may vary.
Reduce the use of oral steroids
NUCALA is NOT a steroid, and when added to your asthma medication, it helps to reduce your use of steroids like prednisone. Your results may vary.

Did you know?

Studies also showed that NUCALA helped* improve asthma control and reduce symptoms. And in a study, people with severe asthma stated that they had a better health-related quality of life after taking NUCALA.

* Based on the limits of the studies, the results are descriptive, and your experience may or may not be the same.

Why would your doctor recommend NUCALA?

You and your doctor are treating your severe asthma, but you may not be addressing one of the underlying causes: eosinophils. Your doctor may give you a blood test that measures your eosinophil count. In clinical studies, an eosinophil count helped identify patients whose asthma was more likely to respond to treatment with NUCALA.

Based on your blood test results, your doctor may recommend adding NUCALA to your asthma treatment plan. NUCALA works with your current asthma medicines to decrease airway inflammation that can trigger severe asthma attacks.

What else should you know about NUCALA?

It's an add-on
NUCALA works in addition to the asthma medicines you already take. It's important to continue to take your current asthma medications as instructed by your healthcare provider.
It goes to a source
Eosinophils are a normal part of your immune system, but in higher numbers, they can cause inflammation. NUCALA helps reduce eosinophils in the blood, so it treats a source of severe asthma, not just the symptoms.
It works over time
NUCALA is an ongoing treatment. You may not feel immediate improvement. NUCALA can reduce inflammation, which can lead to fewer severe asthma attacks, but you may still have some attacks.

What's the next step?

NUCALA may work to help prevent your severe asthma attacks, so it's important to talk to your doctor about it.

  1. Tell your doctor everything you're doing to manage your severe asthma, and talk about how your asthma is affecting your life.
  2. Ask your doctor if adding NUCALA to your current asthma treatment could help improve your severe asthma.
  3. Ask your doctor for a blood test to check your eosinophil level.

Talk to your doctor

Some questions to ask about NUCALA.

Download Discussion Guide

Get more information about severe asthma.

See FAQs

Learn about eosinophils.

Learn more

Talk to your doctor to see if adding NUCALA for your severe asthma is right for you.

Approved Use

NUCALA is an add-on, prescription maintenance treatment for patients 12 and older with severe eosinophilic asthma. NUCALA is not used to treat sudden breathing problems.

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Approved Use

NUCALA is an add-on, prescription maintenance treatment for patients 12 and older with severe eosinophilic asthma. NUCALA is not used to treat sudden breathing problems.

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Do not use to treat sudden breathing problems.

NUCALA can cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your injection of NUCALA. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling light-headed (low blood pressure)
    • rash
    • hives
  • Herpes zoster infections that can cause shingles have happened in people who received NUCALA.

Before receiving NUCALA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your other asthma medicines, including your corticosteroid medicines, unless instructed by your healthcare provider because this may cause other symptoms to come back.
  • have a parasitic (helminth) infection.
  • are pregnant or plan to become pregnant. It is not known if NUCALA may harm your unborn baby.
    • A pregnancy registry for women who receive NUCALA while pregnant collects information about the health of you and your baby. You can talk to your healthcare provider about how to take part in this registry or you can get more information and register by calling 1-877-311-8972 or visit www.mothertobaby.org/asthma.
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use NUCALA and breastfeed. You should not do both without talking with your healthcare provider first.
  • are taking prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and weakness (fatigue).

You are encouraged to report negative side effects of prescription drugs to the FDA.Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.