How NUCALA Works

NUCALA reduces the number of eosinophils (ee-uh-sin-uh-fils) in the blood. Eosinophils are a type of white blood cell that is a normal part of the body's immune system. Too many eosinophils can contribute to inflammation, which is a key component of EGPA. The mechanism of action of NUCALA is not fully understood.


How you will receive NUCALA

  • NUCALA is given as 3 separate, 100-mg injections during the same office visit every 4 weeks.
  • Your healthcare provider will prepare NUCALA and administer it just under your skin (subcutaneously) into your upper arm, thigh, or abdomen.
  • It is recommended that the 3 individual 100-mg injections be administered at least 5 cm (approximately 2 inches) apart.

Once you receive your injections, you may be asked to stay in the office while your healthcare provider monitors you for any allergic reactions, including anaphylaxis. It's possible that some serious allergic reactions can occur hours or days later.


Contact your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction: swelling of your face, mouth, and tongue; breathing problems; fainting, dizziness, feeling light-headed (low blood pressure); rash; hives.


Once your treatment has started, if you need help finding a more convenient site closer to home, such as a local physician's office, contact a Case Manager for NUCALA at 1-833-844-EGPA (3472).

Get more tools

Since EGPA is rare, you're probably no stranger to research and finding answers to your questions. If you'd like to learn more about EGPA and how NUCALA may help, sign up to have helpful information sent directly to you.

Talk to your doctor to see if adding NUCALA for your EGPA is right for you.