Is NUCALA a steroid?

Most patients with EGPA are first treated with corticosteroids, such as prednisone. Some patients taking corticosteroids are able to achieve remission, but some may experience relapses and require additional medicines to treat their EGPA.

NUCALA is different: it's a biologic.

And when it's added to your current treatment plan, it can help reduce your symptoms and flares related to EGPA. Woo-hoo! Did you also know that NUCALA may make it possible for your healthcare provider to reduce your steroid dose? Over half the patients who were being treated with NUCALA were able to have their healthcare providers lower their dose of oral steroids to 7.5 mg a day or less— and 1 out of 5 patients no longer required oral steroids at all. Your results may vary. Ask your healthcare provider about taking NUCALA.

You asked for more.

Significantly more patients treated with NUCALA stayed in remission longer by the end of the 1-year study. And get this—more patients had fewer relapses and a lower daily dose of oral steroids as well. So, what are you waiting for? Talk to your healthcare provider about adding NUCALA to your current EGPA medicines to:

Your results may vary. Ask your healthcare provider if NUCALA is right for you.

* "Complete remission" was defined as no active vasculitis and a prednisone or prednisolone dose less than or equal to 4 mg per day.

"Relapse" was defined as worsening symptoms that required increased steroid dose, and/or increase in dose or start of immunosuppressants, and/or hospitalization.

Have an appointment coming up?

Be ready with questions for your healthcare provider. This Doctor Discussion Guide will allow you to map out questions or concerns ahead of time, so you and your healthcare provider can have a more open and informed conversation.

Approved Use

NUCALA is a prescription medicine used with other medicines for the treatment of adults with eosinophilic granulomatosis with polyangiitis (EGPA).

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Approved Use

NUCALA is a prescription medicine used with other medicines for the treatment of adults with eosinophilic granulomatosis with polyangiitis (EGPA).

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

NUCALA can cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your injection of NUCALA. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling light-headed (low blood pressure)
    • rash
    • hives
  • Herpes zoster infections that can cause shingles have happened in people who received NUCALA.

Before receiving NUCALA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your other asthma medicines, including your corticosteroid medicines, unless instructed by your healthcare provider because this may cause other symptoms to come back.
  • have a parasitic (helminth) infection.
  • are pregnant or plan to become pregnant. It is not known if NUCALA may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use NUCALA and breastfeed. You should not do both without talking with your healthcare provider first.
  • are taking prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and weakness (fatigue).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.