How NUCALA Works


NUCALA targets eosinophils, but what exactly does that mean?

What are eosinophils?

Eosinophils [ee-uh-sin-uh-fils] are white blood cells that are a normal part of the body’s immune system.

Eosinophils play a role in nasal polyps

When you have CRSwNP there is inflammation in your nasal passages. Eosinophils, a type of white blood cell, play an important role in this inflammation. Because surgery doesn’t eliminate this inflammation, the nasal polyps can come back.

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Nasal polyps coming back?

Most nasal polyps have high numbers of eosinophils*

Nasal polyps with high eosinophils have a greater chance of returning after surgery.

*In addition to other types of cells.

NUCALA specifically targets eosinophils

NUCALA is not a steroid, like prednisone; it's a biologic. NUCALA is the first approved treatment that specifically targets eosinophils, a source of inflammation in nasal polyps. It reduces the number of eosinophils in the blood.

It is not fully understood how NUCALA works.

What to expect during your first NUCALA treatment

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In the office

If you want to receive your NUCALA injections from your doctor, you can have NUCALA administered in the office.

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At home on your time

NUCALA can also be taken at home with the Autoinjector. Your doctor will provide information on how to properly inject at home.

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It is important to monitor for serious allergic reactions after injection, either in the doctor’s office or at home. Sometimes serious allergic reactions, including anaphylaxis, can occur hours or days after administration of NUCALA. See risks and side effects.


See what NUCALA can do for you.

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