UNDERSTANDING SEVERE ASTHMA

MAYBE YOUR ASTHMA ISN’T JUST ASTHMA

If you're taking asthma medications regularly and still struggling with symptoms, your severe asthma isn't under control. IT'S. NOT. YOU.

So, what are some signs of uncontrolled asthma?

Using a rescue inhaler more than 2x a week

Is using your rescue inhaler becoming the norm? This could mean using it to control coughing, wheezing, difficulty breathing, or frequently waking up at night from your symptoms.

Treating with oral steroids more than twice a year

Is your asthma uncontrolled? Asthma exacerbations—also known as severe asthma attacks—are when symptoms are not improving and you need to add oral steroids. If this sounds like you, there could be more going on.

One or more hospitalizations a year

Do your asthma attacks send you to the hospital or ER once a year or more? This is a sign your asthma isn’t controlled and you may need additional help.

If this sounds familiar, it’s time to talk to your doctor about your current asthma treatments.

Studies of people with severe asthma showed that ~8 out of 10 had high eosinophil levels.*

What are eosinophils?
  • * Based off 2 studies that looked at medical records of patients with severe asthma and found that 74% and 84% had either high eosinophil levels or were on medication to lower eosinophil levels, or had characteristics of elevated eosinophil levels.
Key source: eosinophils

Eosinophils—a key source of severe asthma

To understand possible causes of severe asthma attacks, it’s important to understand the role eosinophils (ee-uh-sin-uh-fils) can play.

 

Eosinophils are normal white blood cells in your body. If you have severe asthma, you may have increased levels of eosinophils, which can worsen inflammation in your lungs. Inflammation can cause severe asthma attacks.

 

Want to learn more about how NUCALA works?

HOW NUCALA WORKS

Find out if there’s more to your asthma

Here are some next steps you can take:

Schedule simple blood testing

Talk to a doctor about your symptoms and schedule simple blood testing, which can measure eosinophil levels.

Understand your diagnosis

If you receive a severe eosinophilic asthma diagnosis, learn more about your type of asthma and different kinds of treatments.

Ask about adding NUCALA

NUCALA, available as an easy-to-use† Autoinjector for severe asthma, targets and reduces eosinophils.‡ This could help improve your symptoms.

  • †Severe asthma patients rated as easy-to-use after training. Autoinjector for patients 12+. See full Instructions for Use.
  • ‡It is not fully understood how NUCALA works

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Approved Use & Safety Info

Approved Use

Important Safety Information

Approved Use

NUCALA is an add-on, prescription maintenance treatment for patients 6 and older with severe eosinophilic asthma. NUCALA is not used to treat sudden breathing problems.

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Do not use to treat sudden breathing problems.

NUCALA can cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your NUCALA injection. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • rash
    • hives
  • herpes zoster infections that can cause shingles have happened in people who received NUCALA.

Before receiving NUCALA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your other asthma medicines, including your corticosteroid medicines, unless instructed by your healthcare provider because this may cause other symptoms to come back.
  • have a parasitic (helminth) infection.
  • are pregnant or plan to become pregnant. It is not known if NUCALA may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use NUCALA and breastfeed. You should not do both without talking with your healthcare provider first.
  • are taking prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and tiredness (fatigue).

Please see full Prescribing Information for NUCALA.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report negative side effects to GSK at gsk.public.reportum.com or 1-888-825-5249.
Visit GSK Help Center website

Explore the GSK Help Center website to find customer service support and contact information.

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Visit GSK For You website

If you have questions about how to access your GSK medication or need cost information, visit gskforyou.com or call 1-866-GSK-FOR-U (1-866-475-3678).