HOW DOES NUCALA WORK?

NUCALA is NOT a steroid. It’s NOT an inhaler. It’s a biologic! NUCALA does not replace a rescue inhaler or steroids—it works by targeting eosinophils,* a key source of asthma inflammation.

  • Results may vary.
  • *It is not fully understood how NUCALA works.

Watch the science behind NUCALA

WHAT IS A BIOLOGIC?

Biologics are treatments that are derived from natural sources and are used to help target key causes of many conditions, like eosinophils in severe asthma.

Key take-aways:

NUCALA targets eosinophils

Eosinophils [ee-uh-sin-uh-fils] are white blood cells that are a normal part of the body’s immune system.

What this means for your severe eosinophilic asthma: Too many eosinophils may lead to inflammation in your lungs. Inflammation can cause severe asthma attacks.

NUCALA reduces eosinophils

NUCALA is not a steroid like prednisone. It is designed to reduce the number of eosinophils in your blood. It is not fully understood how NUCALA works. Reducing the number of eosinophils in your blood may help reduce airway inflammation. What this means for your severe eosinophilic asthma: NUCALA helps you improve asthma control and helps reduce your use of oral steroids like prednisone. Results may vary. It’s important to receive your NUCALA injection once every 4 weeks as prescribed, even if you’re feeling better.

Simple blood testing can measure the number of eosinophils in your blood

In clinical studies, this helped identify patients whose asthma was more likely to respond to treatment with NUCALA.

What this means for your severe eosinophilic asthma: Based on your test results, along with your medical history and other information, your doctor may add NUCALA to your treatment.

NUCALA has 9+ years in market.

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RESULTS WITH NUCALA

Talk to your doctor to see if adding NUCALA is right for you.

Approved Use & Safety Info

Approved Use

Important Safety Information

Approved Use

NUCALA is an add-on, prescription maintenance treatment for patients 6 and older with severe eosinophilic asthma. NUCALA is not used to treat sudden breathing problems.

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Do not use to treat sudden breathing problems.

NUCALA can cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your NUCALA injection. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • rash
    • hives
  • herpes zoster infections that can cause shingles have happened in people who received NUCALA.

Before receiving NUCALA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your other asthma medicines, including your corticosteroid medicines, unless instructed by your healthcare provider because this may cause other symptoms to come back.
  • have a parasitic (helminth) infection.
  • are pregnant or plan to become pregnant. It is not known if NUCALA may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use NUCALA and breastfeed. You should not do both without talking with your healthcare provider first.
  • are taking prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and tiredness (fatigue).

Please see full Prescribing Information for NUCALA.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report negative side effects to GSK at gsk.public.reportum.com or 1-888-825-5249.
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