For caregivers of patients ages 6–11

Find the information you need to inject with confidence

NUCALA is available in a prefilled syringe for your child aged 6–11. Your child’s doctor will give you the information you need to inject properly and monitor for any allergic reactions. Sometimes, serious allergic reactions, including anaphylaxis, can occur hours or days later.

Check out the video and Instructions for Use below for a step-by-step breakdown on how to use the prefilled syringe at home, plus other useful information about NUCALA for your child aged 6–11.

How to use the prefilled syringe at home

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NUCALA (mepolizumab) Injection 40-mg/0.4-mL

How to Use the Prefilled Syringe

Please see the full Instructions for Use at nucala.com/howtouse

NARRATOR:

This is the How to Use video for the NUCALA (mepolizumab) single-use prefilled syringe for appropriate patients.

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Important information

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Important information

Prefilled syringe

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This how-to-use video offers you help and guidance for administering NUCALA with a single-use prefilled syringe.

Please read the full Instructions for Use contained in the NUCALA carton. Carefully follow this information so that you complete each step successfully. The healthcare provider should show you how to use the prefilled syringe before the first injection. The NUCALA prefilled syringe is only for use under the skin (subcutaneous).

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Know the prefilled syringe

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Know the prefilled syringe

Before use

[labels naming NUCALA prefilled syringe parts]

Gray needle cap (needle inside)

Automatic needle guard

Inspection window (medicine inside)

Stopper

White finger grip

White plunger

NARRATOR:

Please take note of the NUCALA prefilled syringe parts so that you are familiar with them throughout this video and while you are giving the injection. Please examine the prefilled syringe before injecting.

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Know the prefilled syringe

After use

After use, the automatic needle guard is activated and pulls up (retracts) the needle.

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After use, the automatic needle guard is activated and pulls up the needle.

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Know your prefilled syringe

Supplies in carton

  • 1 Prefilled syringe

Supplies not in carton

  • Alcohol swab
  • Cotton ball or gauze
  • Adhesive bandage
  • Sharps disposal container

NARRATOR:

To perform the injection, you will need the NUCALA prefilled syringe. You will also need an alcohol swab, a gauze pad or cotton ball, an adhesive bandage, and a sharps disposal container. These materials are not included with NUCALA, so make sure you have them on hand before you inject.

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Prepare

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Prepare

Take out the prefilled syringe

Take the carton out of the refrigerator and make sure the security seals are not broken.

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Take out prefilled syringe. Take the carton out of the refrigerator, check to make sure the security seals aren’t broken.

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Prepare

Take out the prefilled syringe

Do not use the prefilled syringe if a security seal on the carton is broken.

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If a seal is broken, do not use the prefilled syringe.

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Prepare

Take out the prefilled syringe

Remove the tray from the carton.

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Now, take the tray out of the carton.

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Prepare

Take out the prefilled syringe

Peel off the clear plastic cover from the corner of the tray.

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And peel off the clear plastic cover.

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Prepare

Take out the prefilled syringe

Holding the middle of the prefilled syringe (near the inspection window), carefully take the prefilled syringe out of the tray.

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Holding the middle of the prefilled syringe, carefully take the prefilled syringe out of the tray.

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Prepare

Take out the prefilled syringe

Place the prefilled syringe on a clean, flat surface at room temperature away from direct sunlight and out of the reach of children.

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Place the prefilled syringe down on a clean, flat surface at room temperature away from direct sunlight and out of the reach of children.

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Prepare

Take out the prefilled syringe

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Do not remove the gray needle cap at this step.

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Prepare

Inspect and wait 30 minutes before use

Check that the expiration date on the label of the prefilled syringe has not passed.

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Inspect and wait 30 minutes. Check the expiration date on the prefilled syringe.

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Prepare

Inspect and wait 30 minutes before use

Do not use if expiration date has passed.

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Do not use if expiration has passed.

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Prepare

Inspect and wait 30 minutes before use

Look at the medicine in the inspection window. It should be clear to pale yellow to pale brown in color and without cloudiness or particles.

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Look in the inspection window to check that the NUCALA medicine is clear to pale yellow to pale brown in color and without cloudiness or particles.

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Prepare

Inspect and wait 30 minutes before use

It is normal to see one or more air bubbles.

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It is normal to see one or more air bubbles in the solution.

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Prepare

Inspect and wait 30 minutes before use

Do not use if the medicine is cloudy or discolored, or has particles.

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Do not use if it looks cloudy, discolored, or has particles.

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Prepare

Inspect and wait 30 minutes before use

If the medicine looks cloudy, discolored, or has particles, contact GSK for more information
1-888-825-5249

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If the medicine looks cloudy, discolored, or has particles, contact GSK for more information at 1-888-825-5249.

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Prepare

Inspect and wait 30 minutes before use

Wait 30 minutes before use.

[clock graphic] Wait 30 minutes

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Wait 30 minutes.

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Prepare

Inspect and wait 30 minutes before use

Do not warm the prefilled syringe in a microwave, hot water, or direct sunlight.

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Do not warm the prefilled syringe in any other way. For example, do not warm in a microwave oven, hot water, or direct sunlight.

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Prepare

Inspect and wait 30 minutes before use

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Do not use the prefilled syringe if it has been left out of the carton for more than 8 hours.

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Prepare

Choose the injection site

You can inject in the thighs, abdomen, or upper arm.

NARRATOR:

Prepare and choose the injection site. Choose where to inject in the thighs, abdomen, or upper arm, in the highlighted areas shown here.

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Prepare

Choose the injection site

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Do not inject where the skin is bruised, tender, red, or hard.

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Prepare

Choose the injection site

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Do not inject within 2 inches of the belly button.

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Prepare

Clean the injection site

Wash your hands with soap and water.

NARRATOR:

Prepare and clean the injection site. Wash your hands with soap and water.

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Prepare

Clean the injection site

Clean the injection site by wiping the skin with an alcohol swab and allowing the skin to air dry.

NARRATOR:

Next, clean the injection site by wiping it with an alcohol swab. Allow the skin to air dry.

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Prepare

Clean the injection site

Do not touch the cleaned injection site again until you have finished the injection.

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Do not touch this area again before giving the injection.

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Inject

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Inject

Remove the gray needle cap

Remove the gray needle cap from the prefilled syringe by pulling it straight off, away from the needle (as shown). It may take some force to remove the gray needle cap.

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Remove the gray needle cap. Now, remove the gray needle cap by pulling it straight off, away from the needle – this could take a little force.

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Inject

Remove the gray needle cap

You may see a drop of medicine at the end of the needle. This is normal.

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It’s normal to see a drop of medicine at the end of the needle.

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Inject

Remove the gray needle cap

Make sure you inject within 5 minutes after you remove the gray needle cap.

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Make sure you inject within 5 minutes after removing the gray needle cap.

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Inject

Remove the gray needle cap

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Do not let the needle touch any surface.

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Inject

Remove the gray needle cap

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Do not touch the needle.

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Inject

Remove the gray needle cap

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Do not touch the white plunger at this step. This could accidentally push medicine out, and the full dose will not be given.

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Inject

Remove the gray needle cap

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Do not try to remove any air bubbles from the prefilled syringe.

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Inject

Remove the gray needle cap

Do not put the gray needle cap back on the syringe. This could cause a needle injury.

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Do not put the gray needle cap back on the prefilled syringe. This could cause a needle injury.

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Inject

Start the injection

Use your free hand to pinch the skin around the injection site. Keep pinching the skin throughout the injection.

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Inject.

Start injection.

Use your free hand to pinch the skin around the injection site. Keep pinching throughout the injection.

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Inject

Start the injection

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Insert the entire needle into the pinched skin at a 45° angle, as shown.

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Inject

Start the injection

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Move your thumb to the white plunger and use your other fingers to hold onto the white finger grip.

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Inject

Start the injection

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Slowly push down on the white plunger to inject the full dose.

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Inject

Complete the injection

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Make sure the white plunger is pushed all the way down until the stopper reaches the bottom of the syringe and all of the medicine is injected.

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Inject

Complete the injection

Slowly lift your thumb up. This will allow the white plunger to come up and the needle to automatically retract (pull up) into the body of the syringe.

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Slowly lift your thumb up. This will allow the white plunger to come up and the needle to automatically pull up into the body of the syringe.

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Inject

Complete the injection

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After the injection is complete, release the pinched skin.

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Inject

Complete the injection

There may be a small drop of blood at the injection site. This is normal. Press a cotton ball or gauze on the area and apply an adhesive bandage if you need it.

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You may see a small drop of blood, which is normal. Gently press a cotton ball or gauze on the area and apply an adhesive bandage if you need it.

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Inject

Complete the injection

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Do not rub the injection site.

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Inject

Complete the injection

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Do not put the gray needle cap back onto the syringe.

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Dispose

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Dispose

Throw away the used syringe

Put the used syringe and gray needle cap in an FDA-cleared sharps disposal container right away after use.

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To clean up, put the used syringe and gray needle cap in a sharps disposal container right away.

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Dispose

Throw away the used syringe

If you do not have an FDA-cleared sharps disposal container, you may use a household container that is:

  • made of heavy-duty plastic;
  • able to close with a tight-fitting, puncture-resistant lid, without sharps being able to come out;
  • upright and stable during use;
  • leak-resistant;
  • properly labeled to warn of hazardous waste inside the container.

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If you don’t have an FDA-cleared sharps disposal container, you can use any household container that is made of heavy-duty plastic; is able to close with a tight-fitting, puncture-resistant lid; is upright and stable; leak resistant; and properly labeled to warn that hazardous waste is inside.

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Dispose

Throw away your used syringe

When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of it. There may be state or local laws about how you should throw away used syringes.

  • Do not throw away your used sharps disposal container in your household trash unless your community guidelines permit this.
  • Do not recycle your used sharps disposal container.

Keep your sharps disposal container out of the reach of children.

For more information about safe sharps disposal, visit www.fda.gov/safesharpsdisposal.

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Do not throw the sharps container in household trash unless your community guidelines permit this. Do not recycle your used sharps container. Always keep the sharps container out of the reach of children.

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For More Information

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For More Information

If you have any questions or need more information, talk to the prescribing doctor.

For additional resources and support visit NUCALA.com.

NARRATOR:

If you have any question or need more information, talk to the prescribing doctor.

For additional resources and support visit NUCALA.com

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Trademarks are owned by or licensed to the GSK group of companies.

©2022 GSK or licensor.

MPLVID220002 April 2022.

Produced in USA.

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Instructions for injecting

Storage information

  • Store in the refrigerator between 36°F and 46°F (2°C and 8°C).
  • Keep in the original carton until time of use to protect from light.
  • Do not freeze. Do not shake. Keep away from heat.
  • If necessary, an unopened carton can be stored outside the refrigerator at up to 86°F (30°C) for up to 7 days.
  • Safely throw away the prefilled syringe if it is left out of the refrigerator in the unopened carton for more than 7 days.
  • The prefilled syringe must be used within 8 hours after you take it out of the carton. Safely throw it away if is not used within 8 hours.
  • Safely throw away medicine that is out of date or no longer needed.

Keep NUCALA and all medicines out of the reach of children.

Warning

Warnings

Do not use the prefilled syringe more than 1 time. Throw away the syringe in an FDA-cleared sharps disposal container after the injection.

Do not share the prefilled syringe with other people. You may give other people a serious infection, or you may get a serious infection from them.

Do not use the prefilled syringe if it was dropped or looks damaged.

 

Find answers to the most frequently asked questions about the NUCALA prefilled syringe

MyNucala logo

We’re here for you on your treatment journey

Whether you’re still considering NUCALA or have moved forward with NUCALA as a treatment option for your child 6+, MyNUCALA can support you along the way. MyNUCALA offers ways to help you track progress, stay on track with treatment, guide conversations with your child’s doctor, and more.

The MyNUCALA Support Line is here to help answer questions about the injection process.

Call 1-844-4-NUCALA (844-468-2252), Monday – Friday, 8 AM – 8 PM ET.

If you have questions, contact your child’s doctor or a healthcare provider to see if adding NUCALA is an option for your child’s severe asthma.

We have nurses* available to talk to you about NUCALA

844-4-NUCALA (844-468-2252)