How does NUCALA work?

What's the relationship between severe asthma, inflammation, and NUCALA? Follow these simple steps to find out how it all works.

Eosinophils [ee-uh-sin-uh-fils] are white blood cells that are a normal part of the body's immune system.

Too many eosinophils may lead to inflammation in your lungs. Inflammation can cause severe asthma attacks.

A simple blood test can measure the number of eosinophils in your blood. In clinical studies, this helped identify patients whose asthma was more likely to respond to treatment with NUCALA.

Based on your test results, your doctor may add NUCALA to your treatment. NUCALA is designed to reduce the number of eosinophils in your blood.* *The mechanism of action of NUCALA is not fully understood.

Reducing the number of eosinophils in your blood may help reduce airway inflammation.

NUCALA helps you gain asthma control and helps reduce your use of oral steroids like prednisone.* NUCALA works over time, so you may not feel immediate improvement. It's important to receive your injection of NUCALA once every four weeks as prescribed, even if you're feeling better. * Results may vary.

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Talk to your doctor to see if adding NUCALA for your severe asthma is right for you.

Approved Uses

NUCALA is an add-on, prescription maintenance treatment for patients 12 and older with severe eosinophilic asthma. NUCALA is not used to treat sudden breathing problems.

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Approved Use

NUCALA is an add-on, prescription maintenance treatment for patients 12 and older with severe eosinophilic asthma. NUCALA is not used to treat sudden breathing problems.

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Do not use to treat sudden breathing problems.

NUCALA can cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your injection of NUCALA. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling light-headed (low blood pressure)
    • rash
    • hives
  • Herpes zoster infections that can cause shingles have happened in people who received NUCALA.

Before receiving NUCALA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your other asthma medicines, including your corticosteroid medicines, unless instructed by your healthcare provider because this may cause other symptoms to come back.
  • have a parasitic (helminth) infection.
  • are pregnant or plan to become pregnant. It is not known if NUCALA may harm your unborn baby.
    • A pregnancy registry for women who receive NUCALA while pregnant collects information about the health of you and your baby. You can talk to your healthcare provider about how to take part in this registry or you can get more information and register by calling 1-877-311-8972 or visit www.mothertobaby.org/asthma.
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use NUCALA and breastfeed. You should not do both without talking with your healthcare provider first.
  • are taking prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and weakness (fatigue).

You are encouraged to report negative side effects of prescription drugs to the FDA.Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.