UNDERSTANDING HES

HES IS COMPLICATED–LET’S BREAK IT DOWN

HES (hypereosinophilic syndrome) is a group of rare blood disorders, and it can be difficult to diagnose. That’s because symptoms of HES can be vague, including a general feeling of being unwell, like tiredness. The journey can be frustrating, but you're not alone.

HES symptoms look different for everybody.

Without treatment, hypereosinophilic syndrome symptoms can become increasingly worse. Symptoms can vary by person and can affect different parts of the body like:
HES symptoms: lungs, heart, skin, stomach & intestines, brain & nervous system
Key source: eosinophils

NUCALA gets to a key source—eosinophils.

When it comes to HES, it’s important to understand the role of eosinophils—normal white blood cells that naturally occur in your body.

If you have HES, you have increased levels of eosinophils that can lead to inflammation. This inflammation can worsen your symptoms and cause an HES flare.

While it's not fully understood how NUCALA works, it does help reduce the number of eosinophils in the blood, which reduces the inflammation causing HES symptoms and flares.

Interested in knowing more? Let’s get to it.

HOW NUCALA WORKS

What’s next? Ask about simple blood testing.

Talk to your doctor about all of your symptoms and ask about blood testing to measure your eosinophil count. Your doctor will consider these results and a combination of other factors to help make the right diagnosis.

Curious what else NUCALA can do?

Take a look at the data we’ve gathered to help you understand NUCALA better.

RESULTS WITH NUCALA

Talk to your doctor to see if adding NUCALA is right for you.

Approved Use & Safety Info

Approved Use

Important Safety Information

Approved Use

NUCALA is a prescription medicine for the treatment of people 12 years of age and older with hypereosinophilic syndrome (HES) for 6 months or more.

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

NUCALA can cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your NUCALA injection. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • rash
    • hives
  • herpes zoster infections that can cause shingles have happened in people who received NUCALA.

Before receiving NUCALA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your other medicines, including your corticosteroid medicines, unless instructed by your healthcare provider because this may cause other symptoms to come back.
  • have a parasitic (helminth) infection.
  • are pregnant or plan to become pregnant. It is not known if NUCALA may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use NUCALA and breastfeed. You should not do both without talking with your healthcare provider first.
  • are taking prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and tiredness (fatigue).

Please see full Prescribing Information for NUCALA.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report negative side effects to GSK at gsk.public.reportum.com or 1-888-825-5249.
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