NUCALA gives you the option for at-home or in-office administration.

Talk to your doctor about which option may be right for you.

How to Inject NUCALA At-Home for Hypereosinophilic Syndrome

Your healthcare provider will give you information you need to inject properly and talk to you about monitoring for any allergic reactions. Sometimes, serious allergic reactions, including anaphylaxis, can occur hours or days later. Here you can find videos, instructions, and other useful information on how to use the NUCALA Autoinjector or prefilled syringe. Remember that your dose will require the use of three Autoinjectors or prefilled syringes. Talk to your doctor about any questions you may have.

Storage Information
  • Store in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • Keep in the original carton until time of use to protect from light.
  • Do not freeze. Do not shake. Keep away from heat.
  • If necessary, an unopened carton can be stored outside the refrigerator at up to 86°F (30°C) for up to 7 days.
  • Safely throw away the Autoinjector if it is left out of the refrigerator in the unopened carton for more than 7 days.
  • The Autoinjector must be used within 8 hours after you take it out of the carton. Safely throw it away if it is not used within 8 hours.
  • Safely throw away medicine that is out of date or no longer needed.

Keep NUCALA and all medicines out of the reach of children.

Warnings
  • Do not use any Autoinjector more than 1 time. Throw away the Autoinjector in an FDA-cleared sharps disposal container after your injection. 
  • Do not share the Autoinjector with other people. You may give other people a serious infection, or you may get a serious infection from them. 
  • Do not use the Autoinjector if it was dropped or looks damaged.

Autoinjector FAQs

Expand All Collapse All

  • What should I expect when I receive my injections of NUCALA?

    You will receive NUCALA for HES as 3 separate injections given at the same time in an office visit or at home every 4 weeks. You, your caregiver, or your healthcare provider will inject NUCALA just under your skin (subcutaneously) into your thigh or abdomen. Your caregiver or your healthcare provider may also inject in your upper arm. It is recommended that the individual 100-mg injections be administered at least 5 cm (approximately 2 inches) apart if more than 1 injection is administered at the same site.

     

    If you receive your injection at your doctor’s office, you may be asked to stay in the office so your healthcare provider can monitor you for any allergic reactions, including anaphylaxis. Then you'll be able to leave, though sometimes serious allergic reactions can occur hours or days after you get your dose.

     

    If administering at home, be sure to talk to your doctor about how to monitor for allergic reactions, including anaphylaxis, that can occur after a NUCALA injection, sometimes hours or days after you get your dose.

     

    Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction: swelling of your face, mouth, and tongue; fainting, dizziness, feeling light-headed (low blood pressure); hives; breathing problems; or rash.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • What happens if the medicine looks cloudy, the expiration date has passed, or the Autoinjector looks damaged?

    Do not use the Autoinjector. Contact GSK for more information at 1-888-825-5249.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • Can I change (rotate) the injection site for the Autoinjector?

    You may change (rotate) the site (thigh, abdomen, or upper arm) or move the Autoinjector as long as you have not started pressing down. When the yellow needle guard is pressed, your injection will start right away.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • Why do I need to inject within 5 minutes of removing the clear needle cap?

    This prevents the medicine from drying in the needle. It could affect how much medicine you get.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • What happens if I remove the Autoinjector before the 2nd click, the stopper has stopped moving, or the inspection window is not filled with the yellow indicator?

    If this happens, you may not have received your full dose. Contact GSK for more information at 1-888-825-5249.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • Who do I contact if I need help with my injection?

    Your healthcare provider will be able to help you with any more questions you might have.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • What do I do if I miss a dose?

    You or your caregiver should inject a dose of NUCALA as soon as you remember. Then, continue (resume) your injection on your regular dosing schedule. If you do not notice that you have missed a dose until it is time for your next scheduled dose, then just inject the next scheduled dose as planned. If you are not sure what to do, ask your doctor, pharmacist, or nurse.  

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • How do I store my Autoinjector?

    Store in the refrigerator between 36°F to 46°F (2°C to 8°C). Keep in the original carton until time of use to protect from light. Do not freeze. Do not shake. Keep away from heat. If necessary, an unopened carton can be stored outside the refrigerator at up to 86°F (30°C) for up to 7 days. Safely throw away the prefilled Autoinjector if the unopened carton is left out of the refrigerator for more than 7 days.

     

    Autoinjectors must be used within 8 hours after you take them out of the carton. Safely throw away if not used within 8 hours.

     

    Keep NUCALA and all medicines out of the reach of children.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • What if I’m going on a trip or vacation and need to take my NUCALA with me?

    Store in the refrigerator between 36°F to 46°F (2°C to 8°C). Keep in the original carton until time of use to protect from light. Do not freeze. Do not shake. Keep away from heat. If necessary, an unopened carton can be stored outside the refrigerator at up to 86°F (30°C) for up to 7 days. Safely throw away the prefilled Autoinjector if the unopened carton is left out of the refrigerator for more than 7 days.

     

    Autoinjectors must be used within 8 hours after you take them out of the carton. Safely throw away if not used within 8 hours.

     

    Keep NUCALA and all medicines out of the reach of children.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • Can I reuse my Autoinjector?

    Do not use any Autoinjector more than once. Throw away the Autoinjector in an FDA-cleared sharps disposal container after your injection.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • Can I share my Autoinjector?

    Do not share the Autoinjector with other people. You may give other people a serious infection, or you may get a serious infection from them.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • What should I do if my Autoinjector was dropped or looks damaged?

    Do not use the Autoinjector. Contact GSK at 1-888-825-5249.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • The expiration date on my Autoinjector has passed. What should I do?

    Do not use the Autoinjector. Contact GSK at 1-888-825-5249.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • What should I do if a security seal on the carton is broken?

    Do not use the Autoinjector. Contact GSK at 1-888-825-5249.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.