UNDERSTANDING EGPA

HERE’S THE THING WITH EGPA—IT CAN BE HARD TO DIAGNOSE

That’s because EGPA (eosinophilic granulomatosis with polyangiitis) is a rare disease that can be overlooked. Some of the symptoms can be attributed to other diseases, which can mean seeing multiple doctors and specialists to get to the bottom of it. Sound like you? You’re not alone.

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How to get to an EGPA diagnosis?

First, let’s take a look at the signs.

EGPA symptoms can vary by person, and you’ll likely experience only some of them at any given time. These symptoms can affect different parts of your body, including:

  • Airways
  • Ears, nose, & throat
  • Heart
  • Eyes
  • Nerves
  • Stomach & intestines
  • Kidneys
  • Skin

Second, there are additional things to consider.

Because EGPA symptoms can be like those of other diseases, it can mean considering a combination of factors in order to reach a diagnosis, including:

  • Signs and symptoms
  • Physical examination
  • Laboratory tests
  • Specialized imaging studies
  • A biopsy (removal of a sample of tissue or cells)

Third, consult your specialists.

As you may know, EGPA can be difficult to diagnose. It can take a combination of symptoms and blood testing that measures eosinophil levels to suggest an EGPA diagnosis. To get to an accurate diagnosis, a few different specialists may need to be consulted.

Key source: eosinophils

NUCALA gets to a key source—eosinophils.

When it comes to EGPA, it’s important to know about eosinophils—normal white blood cells that naturally occur in the body.

 

If you have EGPA, you may have increased levels of eosinophils that can lead to inflammation and may cause you to experience more symptoms and flares.

 

NUCALA targets and reduces eosinophils in the blood* and could help reduce your inflammation.

 

Interested in knowing more? Let’s get to it.

HOW NUCALA WORKS
  • *It is not fully understood how NUCALA works.

Next step? Ask about simple blood testing.

Talk to your doctor about all of your symptoms and ask about blood testing to measure your eosinophil count. Your doctor will consider these results and a combination of other factors to help make the right diagnosis.

Ben lives his life with NUCALA

Ben found out he had EGPA during his sophomore year of college. After worsening symptoms, hospitalizations, and many steroids, Ben’s life changed when NUCALA became the first FDA-approved treatment for EGPA. Now Ben lives life on his terms, with NUCALA.

WATCH BEN’S EXPERIENCE

Talk to your doctor to see if adding NUCALA is right for you.

Approved Use & Safety Info

Approved Use

Important Safety Information

Approved Use

NUCALA is a prescription medicine for the treatment of adults with eosinophilic granulomatosis with polyangiitis (EGPA).

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

NUCALA can cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your NUCALA injection. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • rash
    • hives
  • herpes zoster infections that can cause shingles have happened in people who received NUCALA.

Before receiving NUCALA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your other medicines, including your corticosteroid medicines, unless instructed by your healthcare provider because this may cause other symptoms to come back.
  • have a parasitic (helminth) infection.
  • are pregnant or plan to become pregnant. It is not known if NUCALA may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use NUCALA and breastfeed. You should not do both without talking with your healthcare provider first.
  • are taking prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and tiredness (fatigue).

Please see full Prescribing Information for NUCALA.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report negative side effects to GSK at gsk.public.reportum.com or 1-888-825-5249.
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