How NUCALA works

NUCALA reduces the number of eosinophils (ee-uh-sin-uh-fils) in the blood. Eosinophils are a type of white blood cell that is a normal part of the body's immune system. Too many eosinophils can contribute to inflammation, which is a key component of EGPA. The mechanism of action of NUCALA is not fully understood.

How you will receive NUCALA

  • NUCALA is given as 3 separate, 100-mg injections during the same office visit every 4 weeks.
  • Your healthcare provider will prepare NUCALA and administer it just under your skin (subcutaneously) into your upper arm, thigh, or abdomen.
  • It is recommended that the 3 individual 100-mg injections be administered at least 5 cm (approximately 2 inches) apart.

Once you receive your injections, you may be asked to stay in the office while your healthcare provider monitors you for any allergic reactions, including anaphylaxis. It's possible that some serious allergic reactions can occur hours or days later.

Contact your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction: swelling of your face, mouth, and tongue; breathing problems; fainting, dizziness, feeling light-headed (low blood pressure); rash; hives.

Once your treatment has started, if you need help finding a more convenient site closer to home, such as a local physician's office, contact a Case Manager for NUCALA at 1-833-844-EGPA (3472).

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Since EGPA is rare, you're probably no stranger to research and finding answers to your questions. If you'd like to learn more about EGPA and how NUCALA may help, sign up to have helpful information sent directly to you.

Talk to your doctor to see if adding NUCALA for your EGPA is right for you.

Approved Use

NUCALA is a prescription medicine used with other medicines for the treatment of adults with eosinophilic granulomatosis with polyangiitis (EGPA).

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Approved Use

NUCALA is a prescription medicine used with other medicines for the treatment of adults with eosinophilic granulomatosis with polyangiitis (EGPA).

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

NUCALA can cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your injection of NUCALA. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling light-headed (low blood pressure)
    • rash
    • hives
  • Herpes zoster infections that can cause shingles have happened in people who received NUCALA.

Before receiving NUCALA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your other asthma medicines, including your corticosteroid medicines, unless instructed by your healthcare provider because this may cause other symptoms to come back.
  • have a parasitic (helminth) infection.
  • are pregnant or plan to become pregnant. It is not known if NUCALA may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use NUCALA and breastfeed. You should not do both without talking with your healthcare provider first.
  • are taking prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and weakness (fatigue).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.