HOW DOES NUCALA WORK?

NUCALA is not a steroid, it’s a biologic. And it’s a non-surgical treatment option that gets to a key source of the inflammation that can cause your nasal polyp symptoms. It is not fully understood how NUCALA works.

NUCALA gets to a key source—here are the facts:

NUCALA targets eosinophils

Eosinophils [ee-uh-sin-uh-fils] are white blood cells that are a normal part of the body’s immune system.
What that means for your CRSwNP: Too many eosinophils may lead to inflammation in your nasal passages. Because surgery doesn't eliminate this inflammation, the nasal polyps can come back.

NUCALA reduces eosinophils

NUCALA is the first approved treatment that specifically targets and reduces eosinophils.*
What that means for your CRSwNP: Eosinophils are a key source of inflammation in nasal polyps. By targeting eosinophils, NUCALA may help reduce inflammation in your nasal passages.

  • *It is not fully understood how NUCALA works.

WHAT IS A BIOLOGIC?

Biologics are treatments that are derived from natural sources and are used to help target key causes of many conditions, like nasal polyps.

Curious what else NUCALA can do?

Take a look at the data we’ve gathered to help you understand NUCALA better. 

RESULTS WITH NUCALA

Once a month.† At home. On YOUR time.

When it comes to your treatment, convenience is key. The NUCALA Autoinjector can be taken at home–just once a month. Want to see how easy‡ the Autoinjector could be for you to use?

HOW TO INJECT NUCALA
  • †Every 4 weeks.
  • ‡Severe asthma patients rated easy-to-use after training. See full Instructions for Use.

Talk to your doctor to see if adding NUCALA is right for you.

Approved Use & Safety Info

Approved Use

Important Safety Information

Approved Use

NUCALA is a prescription medicine for add-on maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adults whose disease is not controlled with nasal corticosteroids.

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

NUCALA can cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your NUCALA injection. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • rash
    • hives
  • herpes zoster infections that can cause shingles have happened in people who received NUCALA.

Before receiving NUCALA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your corticosteroid medicines, unless instructed by your healthcare provider because this may cause other symptoms to come back.
  • have a parasitic (helminth) infection.
  • are pregnant or plan to become pregnant. It is not known if NUCALA may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use NUCALA and breastfeed. You should not do both without talking with your healthcare provider first.
  • are taking prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, tiredness (fatigue). Mouth/throat pain and joint pain have been reported with CRSwNP.

Please see full Prescribing Information for NUCALA.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report negative side effects to GSK at gsk.public.reportum.com or 1-888-825-5249.
Visit GSK Help Center website

Explore the GSK Help Center website to find customer service support and contact information.

Contact Us
Visit GSK For You website

If you have questions about how to access your GSK medication or need cost information, visit gskforyou.com or call 1-866-GSK-FOR-U (1-866-475-3678).