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How NUCALA works.

NUCALA reduces the number of eosinophils in the blood. Eosinophils [ee-uh-sin-uh-fils] are a type of white blood cell that are a normal part of the body's immune system. Too many eosinophils may lead to inflammation in the lungs that can cause severe asthma attacks. The mechanism of action of NUCALA is not fully understood.

A simple blood test may be done to measure the number of eosinophils in your blood. Your doctor will examine your test results, symptoms, and medications. This will help determine if your asthma is an eosinophilic type. Together, you and your doctor will decide if adding an asthma treatment that specifically targets eosinophils to reduce your airway inflammation can help. In clinical studies, an eosinophil count helped identify patients whose asthma was more likely to respond to treatment with NUCALA.

Reducing inflammation can lead to fewer severe asthma attacks, but you still may have some attacks. Many factors can contribute to severe asthma, which is why it's important to continue to take your current asthma medications as instructed by your healthcare provider.

NUCALA is an ongoing treatment.

NUCALA is given as a single injection by a healthcare provider, just under the skin (subcutaneously), once every four weeks. It's important to continue to receive NUCALA as prescribed even if you're feeling better. If you miss an injection appointment for any reason, talk to your healthcare provider about getting back on track as soon as possible. Call your doctor if you experience any side effects.

  • NUCALA works over time, so you may not feel immediate improvement.
Eosinophils can cause inflammation in your lungs.
NUCALA reduces the number of eosinophils in your blood.
Reducing eosinophils can reduce airway inflammation.
Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Do not use to treat sudden breathing problems.

NUCALA can cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your injection of NUCALA. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling light-headed (low blood pressure)
    • rash
    • hives
  • Herpes zoster infections that can cause shingles have happened in people who received NUCALA.

Before receiving NUCALA, tell your healthcare provider about all of your medical conditions, including if you:

    • have not had chickenpox (varicella) or the chickenpox vaccine.
    • are taking oral or inhaled corticosteroid medicines. Do not stop taking your other asthma medicines, including your corticosteroid medicines, unless instructed by your healthcare provider because this may cause other symptoms to come back.
    • have a parasitic (helminth) infection.
    • are pregnant or plan to become pregnant. It is not known if NUCALA may harm your unborn baby.
      • A pregnancy registry for women who receive NUCALA while pregnant collects information about the health of you and your baby. You can talk to your healthcare provider about how to take part in this registry or you can get more information and register by calling 1-877-311-8972 or visit www.mothertobaby.org/asthma.
    • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use NUCALA and breastfeed. You should not do both without talking with your healthcare provider first.
    • are taking prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and weakness (fatigue).

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.