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I knew my asthma
was severe.
I found out
this cell could be
one
reason why.

Have you thought your current asthma treatments weren't enough for you?

It may be that your asthma is severe. Severe asthma affects a small number of asthma patients. Your doctor may not have used the term "severe" to refer to your asthma. Doctors consider asthma to be severe if to keep your asthma controlled, you need to use:

  • asthma controller medicines, including high-dose inhaled corticosteroids
  • a rescue inhaler as needed
  • Oral corticosteroids (steroids) like prednisone, either short term or every day

People with severe asthma may find their asthma more difficult to control and they may experience more asthma-related symptoms and more frequent attacks.

They may also have a history of severe asthma attacks. These severe asthma attacks are called exacerbations. You may have received a prescription for prednisone from your doctor's office or have had an attack so severe that you needed to go to an ER or be hospitalized. This means your current medicines aren't enough to control your severe asthma.

A severe asthma attack or exacerbation is…

…when symptoms like coughing, wheezing, and difficulty breathing don't improve with your regular home treatment and you need to take a steroid like prednisone or go to the ER or hospital to control the attack.

Did you know? Repeated asthma attacks and inflammation caused by long-term, uncontrolled asthma can lead to more asthma attacks. That's why it's important for you to understand your asthma and work with your doctor to create an asthma management plan.

The role of eosinophils.

Scientists are studying how severe asthma inflammation is caused. The immune system can overproduce a type of white blood cell called eosinophils [ee-uh-sin-uh-fils]. Eosinophils are one kind of white blood cell that can worsen inflammation in your lungs. Inflammation can cause severe asthma attacks.

A simple blood test may be done to measure the number of eosinophils in your blood. Your doctor will examine your test results, symptoms, and medications. This will help determine if your asthma is an eosinophilic type. Together, you will decide if adding a different kind of asthma treatment could help. Your asthma specialist can add NUCALA to your treatment to help reduce your severe asthma attacks and your use of steroids like prednisone.

Learn more about NUCALA.

  • Eosinophils are one of the blood cells that cause airway inflammation.
  • A simple blood test can determine your eosinophil level.
  • NUCALA is designed to target eosinophils.

Remember to control your triggers.

Most people with severe asthma are aware of their triggers and take steps to manage them. But it's a good idea to remind yourself of the things that could be making your asthma worse, and talk to your doctor about different ways to avoid them as a part of your overall asthma management plan.

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Important Safety Information

Do not use NUCALA if you are allergic to mepolizumab or any of the ingredients in NUCALA.

Do not use to treat sudden breathing problems.

NUCALA can cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your injection of NUCALA. Allergic reactions can sometimes happen hours or days after you get a dose of NUCALA. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling light-headed (low blood pressure)
    • rash
    • hives
  • Herpes zoster infections that can cause shingles have happened in people who received NUCALA.

Before receiving NUCALA, tell your healthcare provider about all of your medical conditions, including if you:

    • have not had chickenpox (varicella) or the chickenpox vaccine.
    • are taking oral or inhaled corticosteroid medicines. Do not stop taking your other asthma medicines, including your corticosteroid medicines, unless instructed by your healthcare provider because this may cause other symptoms to come back.
    • have a parasitic (helminth) infection.
    • are pregnant or plan to become pregnant. It is not known if NUCALA may harm your unborn baby.
      • A pregnancy registry for women who receive NUCALA while pregnant collects information about the health of you and your baby. You can talk to your healthcare provider about how to take part in this registry or you can get more information and register by calling 1-877-311-8972 or visit www.mothertobaby.org/asthma.
    • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use NUCALA and breastfeed. You should not do both without talking with your healthcare provider first.
    • are taking prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • The most common side effects of NUCALA include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and weakness (fatigue).

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.